Radio-guided surgery (RGS) has long been crucial in minimally invasive interventions, enhancing patient outcomes through lesion excision. This technique is widely used in procedures such as Sentinel Lymph Node Biopsy and Radio-guided Occult Lesion Localization. RGS bridges molecular imaging and surgical care, enabling real-time intraoperative navigation, and its efficacy largely depends on the imaging technologies available rather than disease-specific radiopharmaceuticals, making advancements in imaging tools key for further improvements in surgical accuracy and patient care.
The POSICS-2 project presents an innovative approach to RGS by replacing traditional probe-based methods with a wireless camera system. The goal is to develop a dual-use, portable, wireless, compact, and lightweight camera for tumour treatment. This advancement aims to improve target detection accuracy, shorten surgery time, and minimize the surgical impact on patients, thereby reducing post-operative effects.
This project builds on the success of POSiCS, funded under ATTRACT phase 1, which validated the simulation concept for medical applications. Additionally, it developed a compact prototype with a large active area, demonstrating the effectiveness of the position-sensitive silicon photomultiplier (SiPM) approach through laboratory testing.
“POSICS-2 has officially embarked on its journey toward becoming a groundbreaking product! The current design reflects a close collaboration with the surgeons at the Hôpitaux universitaires de Genève, who are graciously hosting us in their operating rooms to provide invaluable feedback on seamlessly integrating into their surgical practices. The excitement doesn’t stop there—our innovation has sparked significant interest across various surgical specialities, with other practitioners eagerly inviting us to explore how we can revolutionize and enhance their workflows!”, stated Domenico della Volpe, coordinator of POSICS-2 and Professor at the Université de Genève.
Progress and key milestones achieved
Over the past few months, the research team has been actively advancing the project to reach the Technology readiness level (TRL) 6. For example, in June, they submitted a patent application for POSICS shared between Université de Genève and Fondazione Bruno Kessler, marking a significant milestone in the project’s development, which is now moving towards the creation of a startup.
The consortium has also participated in various conferences to showcase the advances and the impact of POSICS-2. They attended the International SPAD Sensor Workshop (ISSW 2024) in Trento, Italy, which focused on the study, modelling, design, fabrication, and characterization of Single-Photon Avalanche Diode (SPAD) sensors. At the workshop, the team presented a poster showcasing key project updates, including a remarkable threefold improvement in position resolution achieved through the integration of AI.
Furthermore, Prof. della Volpe completed the Innosuisse Business Concept Training course, earning certification from the Innosuisse federal agency. The training provided him with practical tools and insights to advance the project and enhance its business development strategies. Moreover, it fostered connections with entrepreneurs and industry experts who offered valuable feedback and guidance, enabling him to pitch the POSICS-2 project to potential investors and unlocking opportunities for support and collaboration.
Currently, the team is in discussions with the School of Surgery at Geneva Hospital to gather feedback on the final product, ensuring it meets clinical needs effectively. Also, is preparing a proposal for further funding through the SWISS INNOSUISSE framework to support the product’s development and facilitate its entry into the market.
Additionally, they plan to attend the 9th International Conference ANIMMA 2025 in Valencia. This event brings together scientific, academic, and industrial communities actively engaged in R&D related to nuclear instrumentation and measurement methods. At the conference, the research team will present the results of ongoing small-animal testing and upcoming ex-vivo testing, marking a significant milestone for the project.
POSICS-2 main applications
This project focuses on Sentinel Lymph Node Biopsy (SLNB), a critical procedure for the early diagnosis of breast cancer and melanoma. POSICS-2 aims to improve patient’s quality of life during and after surgery by transforming the existing protocol into a less invasive procedure.
The invasiveness of the current approach has several consequences, the most debilitating being lymphedema. This condition affects 20% of surgeries, is incurable, and requires lifelong treatment. It places a significant burden on patients and imposes substantial costs on healthcare systems. If the POSICS camera can reduce the incidence of lymphedema by one-third, it could lead to global savings of €2.1 billion while greatly improving patient outcomes.
Here you can watch the video that Prof. della Vollpe made for the Innosuisse Business Concept Training course:
For more information
Visit the POSICS-2 project site.
